It is said that NH2 and OH groups are involved in the reduction process of metal ions during nanoparticle synthesis. Do these groups get converted to some other groups (their oxidised forms) as a consequence of the reaction?
Do not know about amines, but carbons connected to OH groups can loose electrons and change to aldehyde groups or carboxylic groups.
Several chitosan derivatives might suffer from transformation by self-lystic reaction, while concurrenting with reduction of gold. This issue is discussed in so many articles that you will find soon.
One more thing you may concern is pH of chitosan solution. As it is suspended in acidic solvent, typically in 1% of aceticacid, synthesis of nanoparticles will be under extreamly acidic condition. This will be inevitable due to self-assembly of this oligomer at basic condition (even at around pH 8).
Also, you should preempt stabilizing effects varied by different molecular weights of chitosan.
best wish for your progression!
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