Collagen-containing wound dressings have been used in the treatment of diabetes-related foot ulcers (DFU). Collagen components, such as fibroblast and keratinocytes, are a major part of skin development. Collagen may be harvested from a variety of sources including living and nonliving bovine, porcine, and equine skin. Once harvested (via a proprietary process), a native collagen bioscaffold matrix is created that stabilizes the vascular and cellar components, which become incorporated into the wound bed.1 Preliminary findings suggest that collagen-containing wound dressings may have several advantageous features. Cullen et al2 reported the findings from the testing of an oxygenized regenerated cellulose (ORC)/collagen dressing. After use of the ORC/collagen dressing, researchers analyzed wound fluid and found a significant decrease in collagenase-like activity; gelatinase, matrix metalloproteinase (MMP)-2, and MMP-9 levels; and increased scavenged free radicals and binding of growth factors.For more please at the following link, its free paper.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555551/