What is the earliest age that a child has been diagnosed with type 1 diabetes?

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Methylation analysis relating to cognitive traits - does DNA have to be from the tissue of interest?

Wondering whether the use of DNA from saliva (or non-tissue-specific DNA in general) is generally considered to be acceptable for methylation analysis. I'm interested to look at this within the...

01 February 2014 9,372 5 View

Telomere length measurement by qPCR: which protocol is better - Cawthon 2002 or Cawthon 2009?

It seems to me like the 2009 method is preferable, but many recent papers use the 2002 protocol. Is there any reason for this?

05 June 2013 3,676 1 View

Designing qPCR assay to validate a 3Mb CNV (sybr green or equivalent)

How many primer pairs would I need to design to validate this size of CNV by qPCR? Would one PCR fragment be enough, or would I need several?

04 May 2013 2,759 0 View

Has fine mapping by sequencing the region flanking an associated SNP been rendered obsolete by recent developments e.g. 1000 Genomes?

I am wondering if people are still resequencing regions flanking an associated SNP, in order to identify hitherto undiscovered common variants which may be the causative SNP? Or is this a bit of...

10 November 2012 613 3 View

What's better for DNA extraction, phenol chloroform or salting out?

I'm more used to extracting DNA using spin column kits, but trying to work out what is the best non-kit option, in terms of yield and DNA quality.

09 October 2012 4,534 8 View

I have (Linkage Disequilibrium) LD data for two SNPs - r2 is about 0.14, D' is around 0.8. Could these SNPs be said to be in strong LD?

Is it better to cite D' or r2 values when considering LD?

08 September 2012 306 35 View

Is there any test to determine the cardiovascular risk of patients with obesity? from the perspective of obesity?

We found tests to determine cardiovascular risk taking into account lipid profile, blood pressure, age, history of diabetes, other laboratories. But when weight is involved, there is a paradox. I...

02 March 2021 6,036 1 View

Do I need to introduce HFD to ob/ob mice to obtain a T2DM model?

I am planning to work on T2 diabetic animals and check the efficacy of probiotics. My initial plan is to fed B6 animals with HFD for a while. But now, I have the chance to work on ob/ob mice. My...

18 February 2021 6,896 3 View

How seniors face covid 19 without fear?

Seniors in the world with diabetics and hypertension and heart diseases are millions ,and they are facing covid.therefore we should give them advices and precausions to face covid 19,this...

26 January 2021 8,349 4 View

What is role of chronopharmacology or circadian rhythms in metabolic diseases including obesity, diabetes and cardiovascular diseases?

Chronopharmacology is branch of biological science which deals with daily life, sleep and wake, day and night, feeding and fasting and other effects. we can manage many diseases including...

18 January 2021 9,045 3 View

What type of interventional study is this?

Hi, I'm evaluating some medical papers to write a review, but I'm having trouble defining the study design of the following paper: Neurophysiological recovery after carpal tunnel release in...

04 January 2021 1,571 4 View

Diabetic patients and religiosity?

How to convince a poorly educated diabetic patient, of high religiosity, who believes that complications will definitely occur with the will of the God however he does

29 December 2020 2,304 4 View

Are the same rapid and clinical test of diabetics?

28 December 2020 9,109 12 View

What are the Methods to evaluate nephroprotective activity of herb in diabetic and hypeetensive nephropathy or CKD?

Usualy nephroprotective drugs of plants orgin were evaluted in nephrotoxicity animal model. But CKD secondary to HTN and DM is also common. What are the method to develop these animal model in a...

28 December 2020 161 2 View

Are COVID 19 vaccines reliable for people with medical conditions, like those with respiratory issues, diabetes, heart problems, etc.?

22 December 2020 5,948 7 View

Is it possible to calculate the sample size of a clinical trial with the Cohen formula when there is no similar article?

We are trying to design a clinical trial on type 2 diabetes patients. The main data that we want to assess include FBS, 2hpp, HbA1c, insulin, and HOMA-IR. Also, we will assess the lipid profile...

21 December 2020 2,454 3 View

Vesna Rupcić

I think in utero.We know that in dM gravidarum must have very strong control of diabetes.

Reza Didehdar

Peaks of presentation occur in 2 age

groups: at 5-7 yr of age and at the time of puberty. The 1st peak

may correspond to the time of increased exposure to infectious

agents coincident with the beginning of school; the 2nd peak may

correspond to the pubertal growth spurt induced by gonadal

steroids and the increased pubertal growth hormone secretion