I am seeking guidance on the specific dissolution protocol for administering RO8191 (HY-W063968) to model mice. The dosage is 20 mg/kg, and the intended dissolution regimen is 15% Solutol HS 15 + 10% Cremophor EL + 35% PEG400 + 40% Water. The dosage volume is set at 100 μL per mouse, with an injection cycle of 7 days. Additionally, what temperature should be maintained in the water bath during this process? Any insights or recommendations would be greatly appreciated!
This results in a uniform suspension. Please note that the suspension is generally used for intraperitoneal or oral administration and cannot be used for subcutaneous injection or intravenous injection.
If you have more than one mouse, you can proportionally increase the volume and mass of each component in the above steps.
Note: This preparation must be made fresh before use and cannot be stored. Be sure to include a solvent control in your experiment.
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