We have verified through experiments that Methylprednisolone succinate sodium (HY-B1060) is water-soluble, with a solubility of 50 mg/mL.

Both ultrasonic treatment and heating at 37°C are effective dissolution-aiding techniques. If you observe incomplete dissolution of the product during the dissolution process, you may use a 37°C water bath in combination with an ultrasonic cleaner to facilitate dissolution, thereby ensuring the product is fully dissolved. The answer to this question is provided by MedChemExpress Technical Support.

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Methylprednisolone sodium succinate (MPSS) is a water-soluble corticosteroid ester that is usually prepared as an intravenous (IV) or intramuscular (IM) injectable solution. Its dissolution (or reconstitution) method is defined in pharmacopeial monographs and the manufacturer’s instructions.

General dissolution method (for parenteral use):

Methylprednisolone Sodium Succinate is dissolved using a low-temperature (5–15 °C) high-speed dispersion method in water, often with sodium bicarbonate added for solubilization, followed by pH adjustment to about 7 and sterile filtration to obtain a clear solution.

Dissolution / Reconstitution Method for MPSS

• Solvent: Water for Injection (WFI)
• Temperature: Cool conditions (typically 5–15 °C) to prevent degradation of the labile succinate ester.
• Process: Add MPSS powder to WFI. Use high-speed dispersion or vigorous stirring for complete dissolution. Sodium bicarbonate may be added as a solubilizer (helps maintain ionization and stability). Adjust pH to ~7.0 (physiological range) to obtain maximum solubility and stability. Sterile filtration (0.22 µm) yields a clear, particulate-free solution suitable for parenteral use.
• Notes: Avoid high temperature — MPSS is heat-sensitive and hydrolyzes easily. Solution should be used promptly or stored as directed (light-protected, cold conditions if short-term). This is not just dissolution but a reconstitution and stabilization step, often used in hospital and pharmaceutical preparation settings.