Ofcourse it will affect the performance of the tablets.. Both grade has different level of viscosity and strengths.

I found this article: http://eknygos.lsmuni.lt/springer/367/5-124.pdf

There should be basically no change for the tablet on hardness.

The different between the two are mainly the molecular weight and viscosity

" It can also be seen from Table 59 that there is hardly any difference in the particle sizes of the granules produced with povidone K 25 and povidone K 30.A similar relationship is found when the hardness of placebo tablets is compared. It can Wet granulation: Granulation with binder solution/solvent Dry granulation: Compaction with binder etc. Granules Mixing with disintegrant and lubricant Compression Direct compression: Mixture of all components Fig. 36. General methods of tabletting Table 58. Usual concentrations as a binder Povidone type Concentration in tablet/granules Povidone K 25 2–5% Povidone K 30 2–5% Povidone K 90 1–3% Table 59. The influence of different povidone types in a concentration of 5 % on the particle size distribution of a corn-starch granulate obtained by wet granulation Without Povidone K 25 Povidone K 30 Povidone K 90 Fraction < 50 µm > 99% 28% 27% 23% 50 µm – 100 µm < 1% 23% 22% 10% Fraction > 250 µm – 44% 44% 61% 2.4 Applications of povidone 69 be seen from Figs. 37 and 38 that there is no major difference between povidone K 25 and povidone K 30, even over a range of compression forces, while povidone K 90 gives significantly harder tablets. "

Hope that help

You should consider the dissolution as well when choosing between Povidone K25 and K30. Povidone K30 might help you as I believe it is a stronger binder if your problem is tablet hardness. Better to have a trial compounding using each binders with different percentage per tablet.

Difference between K-25 and K-30 is molecular weight, viscosity.

PVP k-30 will give you larger granules as compare to PVP k-25.

pvp k-30 granulated tablet will disintegrate later as compare to pvp k-25.

dissolution of pvp k-25 higher as compare to pvp k-30.