What is the difference between Multicomponent reactions, cascade reactions, Tandem Reactions, Domino reactions with the example?

More Ramdas Pathare's questions See All

What is an easy method for the deprotection of Benzoyl group?

19 March 2017 5,179 9 View

Can someone provide a protocol for GSIS in Min-6 cells?

Need to transfect Min-6 cells with miRNA (suggest a method please) following which GSIS has to be analyzed. Waiting for some information

17 September 2015 6,042 2 View

Is there a manual or method for extraction of cell free RNA?

I want to extract cell free RNA. Is there any manual method for that and what would be the best starting material - plasma or serum?

11 April 2014 4,060 1 View

what is the simplest definition of ion exchange capacity

What this unit identifies for the ion exchange capacity ca. 0.92 meq. g-1. I am a newcomer in the membrane area. I just started. I highly appreciate your help

08 May 2021 0 0 View

what is the simplest definition of ion exchange capacity

What this unit identifies for the ion exchange capacity ca. 0.92 meq. g-1. I am a newcomer in the membrane area. I just started. I highly appreciate your help

08 May 2021 0 0 View

How the parameters (such as Mw, Chemical bonds, polymer bland and so on) affect the mechanic property of polymer (such as storage, loss modulus) ?

Anyone can recommend any books on such topics? Thanks in advance.

02 March 2021 8,457 2 View

Why almost every element would be metallized in sufficiently high pressure and low temperature?

(This statement is from wikipedia, BTW). What is so special about metallic bond that is limiting high-P low-T state of a matter (as long as individual atoms exist, not white dwarf of neutron star...

02 March 2021 3,309 2 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

Ester cleavage conditions?

Hi all, I need to cleave the ester in Ethyl 2-amino-1H-imidazole-5-carboxylate to make the carboxylic acid and retrieve the product from solution to use in downstream applications of linking to...

01 March 2021 8,766 3 View

Why might my GFP tag be dissociating from my plasmid after transfection?

I have a set of stably transfected cell lines all transfected with plasmids containing GFP tags on the C terminus. During a western blot using anti-GFP antibody, one of my plasmids has dissociated...

01 March 2021 9,310 4 View

Precipitate after adding laemmli buffer to protein solution containing Potassium Acetate?

Hi, I am running a size exclusion chromatography experiment with a buffer containing Potassium Acetate as a salt. I analyse these fractions through SDS-PAGE. After boiling my SEC fractions in...

01 March 2021 2,622 3 View

What is the most suitable server for predicting protein structures in bacteria?

I have used the i-Tasser several times, however it has been unavailable for several days. I tried the swiss-model, but the output was not very pleasant due to the model used. Is there any other...

28 February 2021 4,521 3 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View

Yurii V Geletii

Why not to google before asking?

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.553.6494&rep=rep1&type=pdf

DOI: 10.1002/1521-3773(20000915)39:183.0.CO;2-U

Akash Mamon Sarkar

More generally I would say, in multicomponent reactions bonds are formed one after another whereas in Tendem reaction the bond forming/breaking happening at the same time. Generally Tendem/domino reactions are call in a common name as cascade reaction. The products of these reaction is difficult to obtain in a single reaction.

It's not really necessary the transition state of these reactions would be stable enough, that might be transfer immediately to the next lower energy product.