According to 2002/657/EC, minimum required performance limit (MRPL) means minimum content of an analyte in a sample, which at least has
to be detected and confirmed. It is intended to harmonise the analytical performance of methods for substances for which no permitted limit has been established.
My question is:
(1) In the case of substances for which no permitted limit (e.g., MRL) has been established, how do I establish the minimum required performance limit (MRPL)? And, what is the difference between MRPL and detection capability (CCβ) of substances for which no permitted limit has been established?