Mutations are of different types there are some mutation that are beneficial. Beneficial mutation allow the organism to have a better chance of survival. e.g A gene responsible for disease susceptibility can be mutated in order to give resistance to plant against a particular disease. Such mutations usually this type of mutation is accommodated by the organisms. Harmful mutation on the other hand results in severe consequences on the health of the organism. Sickle cell anemia is an example of natural harmful mutation existing in human beings. Similarly there are other harmful mutations that risks the health of the organism, While some mutations confer no effects on the fitness of the organism and are known as silent mutations.

Polymorphism as is it is obvious from it name poly (many) morph means shapes or form. Genetic polymorphism is means genes exist in different forms just for instance Human blood types are examples of polymorphism, because their different alleles are found at the same locus.

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A mutation is a change in the genetic material (DNA) of an organism, weather harmful or not. Polymorphism is the variety of a specific locus (or gene) in a desired population. Polymorphisms are the result of accumulation of mutations over time. Polymorphisms (genetic variants) of a specific locus may affect a specific phenotype, such as eye colour and sickle cell anaemia (as Muhammad Bhatti motioned).

Kind

Each cell, in order to function correctly, depends on thousands of proteins to function in the right places at the right times. When a mutation alters a protein that plays a critical role in the body, a medical condition can result. A condition caused by mutations in one or more genes is called a genetic disorder. Some mutations alter a gene's DNA base sequence but do not change the function of the protein made by the gene. Such mutations will be present in all descendants of this cell within the same organism, and certain mutations can cause the cell to become malignant, and, thus, cause cancer

In this case, the mutation may enable the mutant organism to withstand particular environmental stresses better than wild-type organisms, or reproduce more quickly. In these cases a mutation will tend to become more common in a population through natural selection.

For example, a specific 32 base pair deletion in human CCR5 (CCR5-Δ32) confers HIV resistance to homozygotes and delays AIDS onset in heterozygotes.

When you mutation occur in the harmful silent (repressed gene) gene leads to derepression of this gene and occurrence of harm=harmful mutation while beneficial mutation is this that cause silencing of harmful gene and leads to repression of this gene

Harmful mutation Kills

beneficial mutation helps in survival

and polymorphism fate is not decided yet