https://www.researchgate.net/post/Can-anyone-help-with-an-entrapment-efficiency-encapsulation-efficiency-calculation

see the answers for this Q.

Good luck.

Hi Khalil Mansoor Abdoh Qasem

"Encapsulation" is a specific terminology referring to the number / quantity of molecules exclusively internalised by a capsule (such as liposome, noisome, nanoliposome, SLN or tocosome).

"Entrapment" is a broad terminology referring to the number / quantity of molecules (e.g. drug molecules) taken inside the core (e.g. hydrophilic material dissolved in the aqueous core of the carrier / capsule) plus those entrapped in the lipid phase of the bilayer of the capsule.

Below are some equations in reply to the rest of your question:

EE % = [W1 - W2 / W1] X 100

DL % = [W1 - W2 / total lipid] X 100

EE: encapsulation efficiency

DL: drug loading

W1 is the content of total drug added; W2 is the content of free (not encapsulated or entrapped) drug.

Note: instead of "total lipid" you can use total ingredients of the capsule (or carrier system).

You can check these articles maybe they can be helpful to you

https://www.tandfonline.com/doi/abs/10.1080/10408398.2021.1987858?journalCode=bfsn20

https://www.tandfonline.com/doi/abs/10.1080/10408398.2022.2070906?journalCode=bfsn20