The drugs in question are mostly chronic maintenance drugs with PO, topical, ophthalmic and tube feeding route. What parameters determine dose intervals?
The two medical terminologies are synonymous and imply the same instruction for the patients in that patients are told to take or administer the drugs twice a day the 2nd dose is supposed to be taken 12 hrs after the time of the first dose).
Your query has already been answered by Getasew Amogne Aynalem
Regarding your question 'What parameters determine dose intervals?'..dose interval is decided on the basis of required concentrations of the drug needed to maintain efficacy, and are decided after studying pharmacokinetics parameters.
As far as I know the actual practice, there is no difference between twice daily and q 12 hours schedule for drug administration. Physicians and pharmacists understand twice a day as q12 hours schedule. But theoretically, there is difference between them in that twice a day schedule does not mean necessarily 12 hours apart and there difference should be considered in case decision is required regarding a patient.
You can see additional idea here below
https://www.sussexpartnership.nhs.uk/sites/default/files/documents/delayed_or_early_dose_guidance_-_ver_1_-_apr_15_-reviewed_unchanged_mar_19_0.pdf
- Badges
- Science topic
- Similar topics
- Clinical Pharmacology
- Dosing