An enzyme that may be genetically less functional in lining cells of the gut (enterocytes) is my focus of attention. In coeliac disease, one sees flattened villi and inflammation. The defect I am researching will reduce cell division in the gut enterocytes and may even increase enterocyte apoptosis, but without inflammation.
Q. How could these processes be observed on gut biopsies where villous atrophy is less prominent?
Q. What defines villous height?
Q. How long can older enterocytes survive in an attached state, given that normally, turnover of the inner lining of the gut is about 48 hours?
dear John L. Whiting,
I have performed experiments on intestinal cells layer, in particular the portion of the intestinal villus from which originate the enterociti is between localized by the villus basal portion and the apical part of the and crypt. I have performed of organ cultures by biopsy in which I put in the cultural midium vincristine for blocking cells in mitosis.
If there is a reduction of cells proliferation, result in a reduction in the number of cells that are dividing.
many greetings,
Dr. Fabio Nobili Ph.D
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