John L Whiting

8 Questions 15 Answers 0 Followers

Questions related from John L Whiting

Did the C677C MTHFR mutation pass from Central America to Spain, or was it the other way round? Does this mutation confer resistance to syphilis?

World's highest prevalence for C677T is in Mexico, followed by Spain, Portugal and Italy. Was this the result of the Spanish 'invasion' of Central America? The only widespread disease that...

07 April 2015 8,442 0 View

In what range might the values for red blood cell sodium normally be? Is this an effective way to find a sodium channelopathy?

I have found red cell sodium values (calculated values only unfortunately) to be 'low' - sometimes 'undetectable'. I am guessing that a value around mmol/Litre

20 March 2015 6,651 3 View

Amino acid profiles (blood): Is it more sensible to evaluate the % abundance of each AA than to look at absolute values falling into the normal range?

For me, the availability of each Amino Acid in fasting blood RELATIVE to all others is more significant metabolically, than the absolute values of each AA (which are currently assessed...

17 March 2015 2,284 4 View

What is the best way to measure enterocyte turnover from biopsies of the gut?

An enzyme that may be genetically less functional in lining cells of the gut (enterocytes) is my focus of attention. In coeliac disease, one sees flattened villi and inflammation. The defect I am...

13 March 2015 3,687 2 View

Is post translational methylation of histidine of skeletal muscle contractile proteins a key determinant of stable muscle growth?

The amount of 3-methyl histadine per gram of skeletal muscle is a constant. Therefore, if there are issues with methylation, one would expect that this must limit the amount of myofibrillar...

11 March 2015 5,587 1 View

Why is the 90 degree angle used to describe a 3 dimensional observable universe?

It seems to me that the choice of the 90 degree angle to divide up physical space is arbitrary and thus, may be wrong. 90 degrees certainly makes things both simple and convenient but that doesn't...

04 August 2014 2,045 5 View

Can anyone provide information on the cerebellar vermis and signs confined to ataxia alone?

I have patients with this strange phenomenon who do not have nystagmus or peripheral cerebellar signs.

08 April 2014 4,820 2 View

What cytokines increase sheddase activity and shedding of angiotensin converting enzyme from pulmonary capillary endothelium?

I have found that a high proportion of chronic fatigue syndrome sufferers have mild to moderate elevations in circulating ACE levels. There is no evidence of pulmonary sarcoidosis. Macrophage...

08 August 2013 7,538 3 View