I need references for the most appropriate method to follow for synthesis 1,3,4 -oxadiazole from reaction aromatic carboxylic acid derivatives with hydrazine -hydrate.…
Best way to convert aromatic carboxylic acid derivatives into1,3,4-oxadiazole by reacting aryl hydrazide(Ar-CONHNH2 with phenyl isocyanate(Ph-NCO) to get carbamide ArCONHNHCONHPh which undergoes cyclodehydration in presence of H2SO4 to get 1,3,4-oxadiazole derivative.