We are currently working on a systematic review and meta-analysis on a new medication for traumatic brain injury. I'm about to include in vivo studies of this drug into the search and analysis. What is the best outcome in these in vivo studies to measure improvement of traumatic brain injury?
For example human have Glasgow Coma Scale, but what is best option for animal models, (except Veterinary Coma Scale) that can be meta-analysed too.
Thank you
Interesting. I actually couldn't understand your main objective for doing this meta-analysis. However, from your statement, I don't know why but I am feeling the abstracted data of yours is more suitable for subgroup analysis.
Well, the number of clinical trials were only 1! And there were 2 registered RCT in clinicaltrial.gov ! So decided to include in vivo studies and perform a subgroup analysis on them and another subgroup analysis for clinical trials
It is not my topic by my approach here would be
i) identify the outcomes that have been used in studies you have already identified in preliminary scoping searches
ii) engage with topic experts about the most important outcomes to use although I think that it is likely to be hard to identify a clear primary outcome in such animal models unless mortality is relevant (maybe it is?).
iii) if there are no (or few) studies then the question is moot - you've not got anything to meta-analyse any way!
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