For exemple in sepsis model some researchers use intravenous inoculation and others intraperitoneal.
Ibtissam,
Are you asking about animal or human studies?
Regards,
Christopher
I think intraperitoneal administration is easier to achieve from the perspective of compound solubility and injection volume. IV administration requires that the compound be dissolved, and limits the injection volume. For a compound with poor solubility, IV may be not allow a sufficient quantity of the compound to be administered in a single dose. Another option, is IV infusion, in which the dose is delivered by an infusion pump over several hours, allowing a larger volume/more dilute solution, and therefore greater exposure to the compound.
Clinical response is the best I think.
Microbiologically, in ICU we like PK/PD and drug monitoring levels.
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