What is the best dose for bleomycin intratracheal for lung fibrosis model?

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James Leigh

5U/Kg body wt has been used in mice

Article Apoptosis and Expression of Fas/Fas Ligand mRNA in Bleomycin...

Luis Veloza

In rats: 2.0 units / kg weight of Bleomycin Sulfate (Blenoxane®, Bristol-Myers Squibb Company, New York) vial with 15 units) in a maximum volume of 0.25 ml.

I have a paper in spanish:

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-55522016000100007

I hope it can help you.

Jens M Poth

It depends.... on the activity of the bleomycin you use and if you want to do multiple dosing.

so, i gues, you need to do a dose finding study. Range: 2-5U/kg.

fyi:

Article Repetitive intratracheal bleomycin models several features o...