Sleep study is not required to diagnose Obesity hypoventilation syndrome.
a body mass index greater than or equal to 30kg/m2 with awake chronic hypercapnia (PaCO2 >45 mm Hg), and sleep-disordered breathing. many have resting hypoxemia. Other disorders that may cause hypoventilation i.e COPD or neuromuscular diseases should be ruled out with spirometry. Approximately 90% of patients with OHS also have obstructive sleep apnea (OSA) and 10% have further worsening of hypoventilation especially during rapid eye movement (REM) sleep.
Maybe not, but it sure helps. I've had a couple of patients where I strongly suspected OHS, but the PSG led me to think otherwise. Turns out they really had neuromuscular disease, and just happened to be obese.