preclampsia is a hetrogenic and complex disease .Although sflt-1 and PGIF ratio has been demonstrated to predict preclampsia in 2nd and 3rd trimester of pregnancy but there is no predictive model in first trimester to predict early onset preclampsia
There is no accurate biomarker to predict preeclampsia. The best protocol is to take a 3day diet diary and if the woman is not eating 50 gms of complete protein per day starting at 12 weeks of pregnancy, and getting adequate but not excessive exercise, then she needs to be counseled on how to alter her diet to get adequate complete protein and stay adequately active in order to prevent preeclampsia.
Preeclampsia is a multifactorial disorder. protein deficiency is not the only sole cause. It is also seen in gravid women with throughout good nutrition .I was more thinking on lines of immunological maladaptation of woman as the main cause along with the women risk factors in history
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