1) I'm looking for any evidences demonstrating the association between MAPK activity and adhesion to microenviroment in lymphocytes, especially in NK lymphocytes.

2) Is MAPK activated in lymphocytes in the microenviroment (e.g., lymphatic tissue) compared to those circulating in the blood? 

3)  Can lymphocytes be released from microenviroment by MAPK inhibition?

I'm not immunologist but hematologist. I often find the changes in lymphocyte nimber in clinical practice when tyrosine kinase inhibitor is used. For example, BTK inhibitor transiently increase circulating malignant cells in chronic lymphocytic leukemia patient. Because the major downstream pathway of BTK is MAPK (ERK),  I speculate that MAPK activity is associated with cell adhesion to microenviroment in lymphocytes.

Let me know the suggestive answer, please.