Dear professors and researchers
Could you please give me some information or introduce related references about this question ?
Thanks in advance
There are several lessons for cosolvents:
-Cosolvents increase the solubility, but strong electrolytes (salts) reduce the solubility of nonpolar solutes.
-Nonpolar solutes are solubilized more efficiently than polar solutes by nonpolar cosolvents → they reduce solvent-solvent (H2O) interactions.
-Generally, there is a linear relationship between the log S (nonpolar) in a mixed solvent and vol.% of cosolvent.
-For less nonpolar solutes there is a downward concavity of the curve (log [solute] vs. [cosolvent]) at high cosolvent composition.
-The effect of multiple cosolvents on solubility is additive and the undesirable effects (toxicity, viscosity) are not.
Thank you so much Dear Andrei, I highly appreciate your contribution regarding my question
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