I'm doing a research to reveal the effect of gestational diabetes on stem cells number and comparing with the non-diabetic group.
and what is the sample size formula for it?
thanks for the reply.....
is this formula I can use?
n= 2SD2 (z(𝛼/2) +Zβ) /d2
Cross-selectional is preferable for quantitative research. But also depends on your study nature. Actually what you want in your findings and who will be the respondent.
I have 2 groups, diabetic group and non-diabetic one and want to find the number of stem cells(outcome variable) in each group then compare them to see if that cells influenced by gestational diabetes or no
Cross-sectional is suitable study design for your research.
Sample size formula for independent samples t-test (comparison of two means) has been presented in the following files:
http://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704_power/bs704_power5.html
https://www.medcalc.org/manual/sampling_comparison_of_two_means.php
357/5000
Dear Sara
It might be more appropriate to focus on the choice of design to be applied.
If you have two groups of (Diab) and (Not Diab) And its outcome (Number of Cel)
and needs verification as to the exposure of the gestational diabetes condition seems
to see that the best suitable design is a retrospective cohort or case control
thanks all for your answer...May I give more details about the study:
I will choose a number of diabetic women and the same number of nondiabetic then I will take sample of blood from each participant and process it at laboratory to identify the number of stem cells in each patient after that want to make a comparison between 2 groups regarding the number of that cells
In my opinion cross-selectional is preferable.
Sample size formula for independent samples t-test.
The two independent groups to be compared are of equal size.
In this case the cross-selectironal is the best option
Cross sectional study design
Two population mean formula for calculating the sample size
In this cases, the dependent variable is the number of stem cells, which is a numeric variable. Gestational DM (present vs absent), is a categorical variable and will be the primary exposure of the study. Thus, the appropriate study design will be cross-sectional study design and the sample size can be calculated using two population mean formula: http://sphweb.bumc.bu.edu/otlt/mph-modules/bs/bs704_power/bs704_power5.html
Almost all the answers are the same.
As a result: 1). Cross sectional study design
2). Two population mean formula for calculating the sample size
The choice is yours))
Please see these various studies below on gestational diabetes mellitus that may allow designs for intervention studies in diabetic and non-diabetic group. Vijayam Balaji, et al. A cohort study of gestational diabetes mellitus and complimentary qualitative research: background, aims and design. BMC Pregnancy Childbirth. 2014; 14: 378. Kristiina Rönö, et al. Prevention of gestational diabetes through lifestyle intervention: study design and methods of a Finnish randomized controlled multicenter trial (RADIEL). BMC Pregnancy Childbirth. 2014; 14: 70. Hui AL1, et al. Barriers and coping strategies of women with gestational diabetes to follow dietary advice. Women Birth. 2014 Dec;27(4):292-7.
I have a doubt .... y can't ths b case control or Cohort?....study looks like a perfect ANALYTICAL STUDY...
As per my knowledge...research can be descriptive, analytical and experimental...of which descriptive and analytical are observational studies and experimental comes unter interventionall studies... descriptive and analytical can be carried out cross sectionaly or longitudinal...
Descriptive studies are done to formulate hypothesis
Analytical to test hypothesis...this is of 2 types
1. Case control... effect to cause...u have effect u go back to check causative factor...also called as a backward looking study(crosssectional)
2. Cohort study...where in u have population who share same characteristic exposed to a risk factor and u follow up to see the effect...(longitudinal study)...@also called as forward looking or prospective study
Experimental study...wherein u prove the hypothesis..
Now coming to ur study..
It is a analytical study...if u chk stem cell number and go back 2 chk gestational diabetes is thr r not thn it is CASE CONTROL study....if u select pregnant women with gestational diabetes and follow them to see the effect thn it's COHORT study
Ths s my knowledge....based on ur study design u can decide...
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Metabolic Diseases
- Glucose Metabolism Disorders
- Diabetes