I know that acetylation is a post-translational modification of tubulin and that it increases their stability but why can this acetylation be increased? And what happens to the neuron with acetylated tubulin?
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Katarzyna Miskiewicz
It is not clear whether acetylation of tubulin has an effects on tubulin stability. Studies rather show that the increase of alpha-tubulin acetylation does not increase stability of microtubules but acetylated tubulins accumulate in stable microtubules. Tubulin acetylation promotes kinesin binding. Changes in the acetylation status of tubulin affect transport. Effects on transport, however depend on cell type and cargo/organelle type.
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