I am looking for How lungs have got an association with liver..what is the underlying mechanism that causes Intrapulmonary dilatations from portal hypertension????
It is not just dilation. there is also aberrant vasculogenesis in HPS; probably VEGF driven. The basic connection seems to be an overflow of the factors driving splanchnic vasculogenesis to reduce portal hypertension, into the pulmonary system leading to undesired aberrant vessel formation and dilation of existing vessels. This is seen in experimental models.
Anoher cause implicated is the bacterial translocation , activate NO , VEFG, ET1 and more. Reciently we have a patient who died 2 month later the diagnosis. Very bad prognosis.