Migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms.  Typically the headache affects one half of the head, is pulsating in nature, and lasts from 2 to 72 hours. Associated symptoms may include nausea, vomiting, and sensitivity to light, sound, or smell. The pain is generally made worse by physical activity. Up to one-third of people with migraine headaches perceive an aura: a transient visual, sensory, language, or motor disturbance which signals that the headache will soon occur. Occasionally an aura can occur with little or no headache following it. Migraines are believed to be due to a mixture of environmental and genetic factors. (Source: Wikipedia)

The second link gives a list of 18 symptoms that one is having migraine. (Aura, Depression, Irritability, etc)

A recent interview in Science Magazine (third link) details about the "Science of Migraines). Excerpts from this link:

"Q: What is the most cutting-edge treatment today?

A: The mainstay acute treatment for migraines are a class of drugs called triptans, which act on serotonin receptors. Serotonin is thought to be the underlying neurotransmitter involved in migraine, based on a lower than normal level of serotonin (5-HT) which increases during attacks. There's also a strong relationship between depression [which is linked to abnormal serotonin levels] and migraines: People with depression are more likely to get migraines, and people with migraines are more likely to be depressed. It's not entirely clear how triptans work, but they are able to abort attacks in some patients. They are wonderful drugs, but not everyone responds. The field is now wide open for new drug targets, especially ones that do not constrict blood vessels like the triptans."

[See third link for full interview]

http://en.wikipedia.org/wiki/Migraine

http://www.health.com/health/gallery/0,,20537878,00.html

http://news.sciencemag.org/brain-behavior/2015/02/science-migraines

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