Dear Hadeel, It indicates the existence of an inflamatory process in action.
indicates increased inflammation, may be due to infection, inflammatory condition, morbid obesity
A raised CRP indicates inflammation. The level can be tracked over time to assess an increase or decrease in the inflammatory process, and response to treatment.
Dear Hadeel: I agree with what most of the colleagues said, that it's non specific but my denote inflammation going on somewhere in the body, it's more beneficial if we know where the inflammation is, so we can monitor the improvement.
However, let me add, that in our practice in bariatric surgery, we see it increased in many asymptomatic patients preoperatively
We are in the process of studying wether there is a relationship between obesity and elevated markers, as most of the literature considers obesity as an inflammatory state
I agree with most comments. CRP is an indicator of the presence of inflammation. What has not been mentioned is that the presence of inflammation before surgery is a risk factor. It means that the risk to develop complications after surgery is increased. It should urge the surgeon to be more defensive and to limit the operation to "damage control". This implies for instance that the diseased organ is removed or the abscess is drained without constructing hazardous anastomoses. Especially the presence of infection in the operative field has a high risk. There is not a very close correlation between the level of the CRP and the level of risk. For that purpose plasma albumin furnishes a better estimate of the level of risk.
Dear Hadeel, high level c.protein indicates the existence of an inflamatory process in action,but it is non specific marker for type inflammation
It is a generalised marker that is non-specific for inflammation. It is not related to any specific conditions. It is useful to track the response to therapy, after the source of inflammation has been identified by clinical assessment, and clinico-pathological, clinico-radiological, or correlation with other diagnostic modalities.
Esteemed Hadeel Albayati, Although you didn´t specify which surgery you're due to operate on, but that's an alarm that there is an inflammatory process in-course prior to surgery of that patient.
As mentioned by the previous physician it is a generalised marker of inflammation. However if it is raised in children it is likely to be because of appendicitis along with other clinical findings. In post operative period after colonic anastomosis rise in CRP is an indicator for leak. In pancreatitis if CRP is >150 It usually indicates severe pancreatitis.
Though nonspecific, significantly high CRP levels prior to elective surgery must be alerting about an infective process complicating the index pathology, like a tumor microperforation, The situation must be evaluated based first on clinical findings (symptoms,fever, abdominal exam findings) and maybe supported by WBC counts and more specifically procalcitonin levels.
It is an inflammatory protein produce by liver. In preoperative setting we should distinguish between infectious conditions where it is just be consider as a non specific marker that may be use to monitor the recovery and in non infectious conditions it may indicate a starting infectious process that may prompt further investigations or to delayed the surgery untill the situation is under control as for implant surgery.
Besides all evidence and relative litterature and because we operate patients and not lab values: in my experience (I am not claiming a statement), high PCR in urgency context surgical patient means a lot of trouble for the surgeon ( I call it disaster value when above 15)
I think the above answer by Dhia Hussain Al-Delemy is the answer to a different question by mistake.
La proteína C reactiva (PCR) es una proteína producida por el hígado que aumenta en respuesta de la inflamación, es decir, cuando existe alguna inflamación en el cuerpo, y no es específica. Antes de la cirugía tener una PCR significa que existe un proceso inflamatorio y como no es específico, se debe investigar la razón, y ayuda mucho la clínica que presente el paciente, es decir, una adecuada Historia Clínica y las investigaciones en relación con la sintomatología deben confirmar la hipótesis planteada. Los niveles muy altos puede significar la existencia de una infección grave u otro trastorno.
The two answers above to 'personality' and 'educational system' have no relevance to an elevated CRP level prior to surgery, asked in this question.
They seem to be in the wrong thread.
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