It is the ability of the plant leaf extract to inhibit the growth or completely kill the pathogenic bacteria. If it inhibits the growth of the pathogens, it is said to be bacteriostatic and if it completely kill the pathogens, it is said to be bactericidal..
The antimicrobial activity of medicinal plant leaf extracts against pathogenic bacteria is the ability of these extracts to inhibit or kill pathogenic bacteria, often through the presence of bioactive compounds such as secondary metabolites with antibacterial properties. There are several mechenisms of this antimicrobial activity.
Phytochemicals: Medicinal plants contain various bioactive compounds, such as alkaloids, flavonoids, tannins, phenolic compounds, and essential oils. Many of these compounds have been shown to possess antimicrobial properties. For example, flavonoids and tannins can disrupt bacterial cell membranes and inhibit enzymatic processes critical for bacterial growth.
Disruption of Cell Membranes: Some plant extracts can disrupt the lipid bilayer of bacterial cell membranes, leading to increased permeability and leakage of intracellular components. This disruption can result in cell lysis and bacterial death.
Inhibition of Enzymes: Certain plant compounds can inhibit specific enzymes essential for bacterial metabolism and replication. For example, polyphenols can interfere with enzymes involved in DNA replication or protein synthesis.
Oxidative Stress: Some plant compounds act as antioxidants, effectively neutralizing reactive oxygen species (ROS) within bacterial cells. By reducing ROS levels, these compounds can protect bacterial cells from oxidative damage, contributing to their antimicrobial activity.
Synergy: Medicinal plant extracts may contain multiple bioactive compounds that work together synergistically to enhance their antimicrobial effects. This can make it more difficult for bacteria to develop resistance to these natural compounds.
Specificity: The antimicrobial activity of plant extracts may vary depending on the specific bacterial strain. Some plant extracts are more effective against certain types of pathogenic bacteria than others due to differences in bacterial cell wall structures and metabolic processes.
It's important to note that the antimicrobial activity of plant extracts can vary widely depending on the plant species, the extraction method, and the concentration of bioactive compounds in the extract. Additionally, scientific studies typically involve detailed testing, such as agar diffusion assays or minimum inhibitory concentration (MIC) tests, to determine the effectiveness of plant extracts against specific bacterial strains.
Pathogenic bacteria such as S. typhi, E. coli, L. monocytogenes, etc., generally harm the human body in various ways by releasing harmful toxins inside the body. Plants have the natural power to kill bacteria due to several secondary metabolites, such as alkaloids, flavonoids, terpenoids, etc., present inside their root, stem, or leaf.
Therefore, extraction of root, stem, or leaves using various solvents can be used to kill such harmful bacteria.
The ability of plant extract to inhibit growth or kill microbes such as bacteria or fungi, is called its "antimicrobial activity".