Diabetes is very important disease to be tackled with understanding of anatomy, histology, pathology, pharmacology, so its blood supply, drainage, hormones, receptors, break down of insulin in different organs and supply to target organs like skeletal muscles, adipose tissues are essential part, so many people do not know its location, blood supply, nerve supply, break down,etc, Review articles related to general overview with latest updates are essential for a scientist to seek more insight for these questions.