What if I don't use copper in the reaction between linear alkyne and azide?

Mohammed A. A. Abdullah @Mohammed-Abdullah-39

28 March 2017 1 279 Report

I need to have a ligation reaction with slow rate, I don't need the fast click reaction

What is the rate of this reaction without copper is that work with some extent?

Hi, you can try Copper-Free Click chemistry. Check out the Sigma-Aldrich website, there are varieties of alternative click chemistry links for you to use.

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