We know that most of the major drugs and antibiotics resistance are due to the poor treatment practices. Thus, we search for new drug targets and new drugs. If the similar trend follows we run out of all the possible drug targets sooner or later. Then what? Instead of investing huge amount of money in research which will become useless after the resistance has occurred, shouldn't we focus on educating people first?
hi see these
https://www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
https://books.google.iq/books?isbn=0128012730
Hypothetically speaking we do run out of targets; which was thought to be a distant reality and now is a pressing issue. We will have to resort to pro-drug systems where a universally toxic compound is converted to a nontoxic precursor which can be processed by an enzyme only present in target organism cytosolic proteome. This method is very effective and is the basis of activity of some of the most successful and long standing antibiotics (Isoniazid, artemisinin). However such compounds are difficult to design because of lack of information on xenobiotic modifying enzymes of various organisms. Also, it adds a dual exponential degree of resistance frequency in both target and prodrug activating enzyme. Some highly essential enzymes like isoprenoid, amino acid or nucleotide synthesis/salvage can be exploited to activate designer prodrugs releasing highly potent toxins inside the target organism. As far as educating people is concerned there is a huge controversy on whether incomplete course of antibiotics is the main cause of resistance. Please see article and news in following links:
http://www.bmj.com/content/358/bmj.j3418
Article The antibiotic course has had its day
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