What glycine work in cell wall of bacteria?

26 January 2018 13 5K Report

Bacterial cell wall

Peptidoglycan is a polysaccharide made of two glucose derivatives, N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM), alternated in long chains. The chains are cross-linked to one another by a tetrapeptide that extends off the NAM sugar unit, allowing a lattice-like structure to form. The four amino acids that compose the tetrapeptide are: L-alanine, D-glutamine, L-lysine or meso-diaminopimelic acid (DPA), and D-alanine. Typically only the L-isomeric form of amino acids are utilized by cells but the use of the mirror image D-amino acids provides protection from proteases that might compromise the integrity of the cell wall by attacking the peptidoglycan. The tetrapeptides can be directly cross-linked to one another, with the D-alanine on one tetrapeptide binding to the L-lysine/ DPA on another tetrapeptide. In many gram positive bacteria there is a cross-bridge of five amino acids such as glycine (peptide interbridge) that serves to connect one tetrapeptide to another. In either case the cross-linking serves to increase the strength of the overall structure, with more strength derived from complete cross-linking, where every tetrapeptide is bound in some way to a tetrapeptide on another NAG-NAM chain.

Further detail can be found via below mentioned link...

http://library.open.oregonstate.edu/microbiology/chapter/bacteria-cell-walls/

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أ.م.د.صلاح حسون جبار

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Qassim Kshash

Dear Dr.Joseph

Thank you very much for you explanations ad link

I am pleasure you read and answer question

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Qassim Kshash

Dear Dr. Monyer Abd Al-Fatlawi

please more notes

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Qassim Kshash

My friend Dr.Salah

Thanks a lot and good luck for all

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Munaf A. Al-Ramahee

I have no idea. Thank you for sharing your question with me.

Qassim Kshash

Dear Dr. Munaf A. Al-Ramahee

Thanks a lot

Wael Mohamed Abu El-Wafa

please read this paper and good luck

Article Mode of action of glycine on biosynthesis of peptidoglycan

Qassim Kshash

Dear Dr.Wael

I thanked very much for your response and articles you send

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Qassim Kshash

Thanked for all whom participate

Qassim Kshash

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Ruaa SH Redeiny

Article Mode of action of glycine on biosynthesis of peptidoglycan

Wisam Atiyah

The mechanism of glycine action in growth inhibition was studied on eight different species of bacteria of various genera representing the four most common peptidoglycan types.

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