I have studied a lot about oxidative stress in COPD and asthma and have heard a bit about its induction during environmental factors. For e.g. the heat of cold induces it. Actually, I don't know the molecular mechanism. Cancer cells have high oxidative stress too.
Oxidative stress is related to cellular respiration and metabolism. Factors that affect the effectiveness or rate of cellular respiration will increase the production of oxygen radicals. Cellular respiration is not 100% effective and there is a small production of radicals under "normal" conditions which are disproportionally increased during stress. Some environmental factors, like radiation, will directly create oxygen radicals by damaging cellular components. Oxidative damage only indicates that radicals are attacking multiple components in that cell but the origin of those radicals is not always clear.
Numerous environmental stimuli can induce oxidative stress--e.g. cigarette smoking. The source of the reactive oxygen species (ROS) becomes a little more difficult to determine, but it is likley that the indivdiual sources may not be as important as the overall change in oxidative state. Major sources of ROS come from cellular respiration, NADPH oxidases, etc..., but this should always be considered in the context of the available antioxidants (glutathione, etc...). We need a little ROS for normal cell signaling and immune response, but the issue becomes when too much is generated or overwhelms the available antioxidants, and in this case oxidative stress occurs. If you want a good review on oxidative stress, check out Hallwell and Gutteridge's text, Free Radicals in Biology and Medicine. It's a great book.
Research area : Oxidative stress&Antioxidants&Stress and disseasses, Title for ISANH (International Society for Antioxidants in Nutrition and Health) Congress who will be in April 2014 (Riga, Latvia (Lettonie), Europe. Please, check in your Planner Book. Hope, that with will be very interesting and important for much.
Thanks. In most of chronic diseases, we see that oxidative stress is problematic. In asthma, COPD, .... Why its up? Why in most of these diseases antiodixant system is down.
Jamalkandi, ALL diseases are caused by ROS and our antioxidant system is not down as in unfunctional rather inefficient because of lack of antioxidant matter....
You can compare the entire system with a fire .... When you use crude oil you will have a lot of toxic waste in te process. Same goes for our body "high quality food " prepared in a proper way will result in very little ROS... and small amount of extra antioxidant fruit or vege will compensate and result in a healthy body.
The more you ask from the body the more antioxidant is needed as in top sport ... goes for all kind of load factors included mental, emotional, stress etc....
Just a matter of balance ... equilibrium ...
Does somebody work some research about antioxidants? I work on some fungal extacts with in vitro comet assay.
Just "Google" on ORAC and you will find a lot of websites with lists of ORAC values for different fruit and vegetables .....
Hello,
Some of the factors affecting oxidative stress can be broken down into endogenous and exogenous factors. Endogenous oxidative stress can come from activated cells, like neutrophils, which produce MPO when activated, which can result in the formation of hypochlorous acid, a potent oxidant. Also, the innate production of endogenous antioxidants like GSH or NRF2 activity will affect how the body deals with oxidative stress. If one's endogenous antioxidant response system is compromised, oxidative stress levels will rise.
Exogenous oxdiant stress can come from the inhalation of toxic gases, like chlorine for example. Other inhalational exposures to substances like ozone, ammonia compounds and even diesel exhaust can exacerbate lung injury and induce the production of ROS. Chlorine, for example, breaks down into HCL and HOCl when in contact with water through a hydrolysis reaction. I have attached some papers that might help explain some of these concepts.
Best of luck!
Toby
Article AEOL10150: A novel therapeutic for rescue treatment after to...
Here is another publication regarding the effects of oxidative stress on airway injury.
Article Dimethylthiourea protects against chlorine induced changes i...
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