What drug can activate the muc5b expression in lung?

02 February 2020 1 6K Report

I want to know how to regulate the deposited nanoparticle in alveoli via mucociliary clearance. among diverse modulatory mechanism, espically, i want to investigate about the effect of muc5b. Is there a recommended drug?

Riaz A. Khan

Check out the followings:

Phorbol 12-myristate 13-acetate (PMA)

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/muc5ac

Am J Respir Cell Mol Biol. 2017 Jul;57(1):91-99. doi: 10.1165/rcmb.2017-0046OC.

https://www.nature.com/articles/s41467-018-07768-9

https://www.proteinatlas.org/ENSG00000117983-MUC5B

Drug Des Devel Ther. 2019; 13: 3259–3268.

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/muc5ac Article Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis

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