A study performed at the University of Michigan examined whether brain activity is associated with treatment response to exposure-based CBT.
Eighty-seven patients with OCD were randomly assigned to receive 12 weeks of CBT or a control intervention called stress management therapy. Before treatment, researchers conducted functional MRI (fMRI) brain scans while patients performed a series of tasks. They completed the symptom severity scale Yale-Brown Obsessive Compulsive Scale (Y-BOCS) throughout treatment.
The patients with the most significant response to CBT showed more activation in several brain areas before starting treatment. The active regions are associated with cognitive control and reward processing. These data suggest that brain scans could identify biomarkers to personalize treatment in OCD.
Check this out: Aust N Z J Psychiatry
. 1992 Dec;26(4):684-6. doi: 10.3109/00048679209072111.
Buspirone and fluoxetine in the treatment of OCD
F Judd, S Ellen, T Norman
- PMID: 1476539
- DOI: 10.3109/00048679209072111
Have not used Buspirone myself but the clinical experience of my senior colleagues suggests that it does not help.
A controlled trial found buspirone, a 5-HT1A partial agonist, as efficacious as clomipramine in the treatment of OCD (the response rate for both agents was greater than 55%), but this finding has not been confirmed so far. I don't have any clinical experience it can help in OCD disease unless associated with Clomipramine or with a potent serotonin-re-uptake inhibitor (SSRI) such as fluvoxamine, paroxetine, sertraline, fluoxetine and citalopram. Following
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