There are many reports stating the presence of CMV in glioma patients. Does it play any role in glioma? Does it cause any problem in glioma patients?
CMV showed a tropism for macrophages and may be an association through evolution.
Supposed to be work as macrophages, an example of co-evoultion.
Cytmegalo virus belongs to the herps group. It normally present in majority o population, but remain dormant , the dormancy breaks when the immune system weakens. thus it mainly become active and cause complications in situations like 1. cancer patients receiving chemotherapy
2. organ transplant recipients
3. persons with HIV infections
4. babies born to women exposed to CMV during pregnancy
5. those suffering with Chronic infections such as Chronic Lyme disease or other zoonotic infections
Why is that cmv remains as dormant in majority of population? But seems like "cancer patients receiving chemotherapy" is important and valid, considering this situation.
"Oncogene" is prevailed in every body, agree, why not it active in all, the same reason, why the CMV remain dormant in some.
CMV triggers a feedforward mechanism of gliomagenesis by inducing tumor-supportive monocytes.
To vakamullu: interested in reading the article supporting your answer.. can pl post the link of that article.
This commentary may give some nice insights...
http://clincancerres.aacrjournals.org/content/17/14/4619.long
Just another new paper on this subject: http://cancerres.aacrjournals.org/content/73/11/3441
Have been doing some research into the possibility that CMV may be involved in outbreaks of disease. As part of this work looked at the time trajectory of cancers in the USA, see http://www.hcaf.biz/2012/Cancer_costs.pdf and the cancers showing highly non-linear behaviour seemed to include those which have been implicated as being CMV sensitive. Have published two reviews attempting to build a framework within which to understand how CMV could be promoting wider disease within which cancer is an obvious component. In the UK have noted that emergency admission for cancer lags by about one to two years behind the proposed outbreaks. More detail at http://www.hcaf.biz/emergencyadmissions.html
HCMV paticipation in the formation of Glioma or balstoglioma starts with the Latency Associated Transcription of the most herpes family of viruses specially the most neuroinvasive virus CMV RNA proliferation sub-nucleusly. It starts as early as the first trimester of the pregnancy. Its productive neuronal infection in the fetus is directly proportionate to the immune status of the mother. Before it is recognized as a full blown Glioma, its presentation of a variety of symptoms manifests right from early childhood and eventually form the glioma.
CMV RNA proliferation in the nucleus of the targeted neurons play a significant role to alter the anatomical state of the effected group of neurons.
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