For drug delivery to brain, what are the routes of administration? (like intracarotid etc). What are their advantages and problems?

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Manoel Jacobsen Texeira

Intracarotid Chemotherapy for gliomas

Intraventricular opioids and baclofen for pain and dystonia

Intraparenquimatous throphic factors

Advantages: higher local concentration

Better efficacy

Reduced side effects

Sivashanmugam A

Manoel texeira these advantages u have mentioned are for what route ?? or you have generally said for drug delivery in brain...

Manoel Jacobsen Teixeira

The route is intrarterial (carotid arteries) or intrathecal.

Yours

Dr Manoel Jacobsen Teixeira

Khalid Iqbal

Advantage: drugs that cannot cross BBB and hence higher local conc. as mentioned by Manoel.