Foam cells are lipid-loaded macrophages and neutrophils that are generated from a massive uptake of oxidized lipid. Foam cells serve as the hallmark of early stage atherosclerotic lesion formation. but they can be found in acne lesion
What do you think about foam cells in acne lesion? what is the role of foam cell in pathogenesis of acne vulgaris?
Article Common Pathogenesis of Acne Vulgaris and Atherosclerosis
Why foam cells are in acne lesion？ How neutrophils and macrophoges recognize the sebum? How did foam cells develop in acne lesions? What are the pathological changes within foam cells of acne lesion? Lipids accumulated in foam cells suggested lipid metabolism is in disorder. which kind of medicine can promote lipids efflux from cells? Isotretinoin is popular in treatment of acne vulgaris. Does Isotretinoin promote lipids metabolism of acne patients? ......
The development of theory of modern medicine is based on physiology, anatomy, pathology, pathophysiology and other scientific theoretical system. Foam cell is an important pathological changes in acne lesion. To explore the pathogenesis of acne must be based on this important pathological change. There are many articles about the pathogenesis of acne published in different journals, however, this articles have never refer to the important pathological change (foam cells in acne lesion）.
We are all studying signaling pathways, and believe that signaling pathways play an important role in the pathogenesis of diseases. Signal is a word that represents the physical energy of a message. The energy of the signal is slightly and gently coming from faraway. We have found the abnormal signal and keep on study the signal pathway. Then, the problem is coming out. Where is the signal source? What happen in the signal source? Why does the signal source emit such an abnormal signal? We study hard on the signal pathway, but ignored to study the signal source. It seems that we are enjoying the sun shine but not seeing the sun in the sky. The blind men in Aesop's fables touch the elephant only know part but don't know all of the elephant.
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