Endotoxin can possibly be neutralized in vivo by diverse substances. The endotoxin- neutalizing substance complex must be removed from the body before it could cause CD14-TLR4-mediated activation of leukocytes and release of inflammatory cytokines leading to ill-effects of endotoxemia. A single mechanism or it will depend on the type of the complex formed?
good evening sir,
In human medicine an extracorporeal hemoperfusion system is there in which blood from femoral vein is circulated through toramymyxin cartilage composed of polymixin B covalently immobolized polystyrene derived fibers. Polymixin B interact with lipid A fatty acid of endotoxin.
http://www.ncbi.nlm.nih.gov/pubmed/10227782
https://www.youtube.com/watch?v=HWQPQBNgpuA
Hi Gaurav,
Thanks for the answer. In fact, I was aware of this system (a sort of hemodialysis) to remove endotoxin by polymyxin. Rather I was curious to know about the fate of endotoxin trapped by its binder in vivo. If we consider reticuloendothelial system, it is likely to invoke innate immune system in somewhat altered manner (LPS in the endosomal compartment also detected by innate PRRs, until and unless it is degraded by the enzymatic system therein).