In a prospective study on patients with pelvic malignancies undergoing pelvic radiotherapy, we found an association between vitamin D deficiency and severity of radiation induced proctitis. This association was independent from age, gender, cancer type, and BMI. What could be the mechanisms behind this association?
Hi
VitD is known to have anit-inflammatory effects beside its role in ca+2 metabolism. It could be that VitD deficiency is associated with activation/triggering of pro-inflammatory cytokines within the intestinal wall or preventing healing.
Wishes,
Bassem
Hi
VitD is known to have anit-inflammatory effects beside its role in ca+2 metabolism. It could be that VitD deficiency is associated with activation/triggering of pro-inflammatory cytokines within the intestinal wall or preventing healing.
Wishes,
Bassem
Hi
there is a considerable body of work suggestion that vitamin D has anti-inflammatory effects in inflammatory bowel disease (IBD), particularly from animal models of IBD (Cantrona and others). The human translation is less clear at this point, but emerging evidence suggests that vitamin D supplementation may prevent relapse in RCTs in IBD. As well as anti-inflammatory effects, newer mechanisms such as effects on autophagy, gut barrier functional and on microbiota have been suggested for vitamin D.
You may care to review the work done on Gc protein, sometimes called Vitamin D- or Vitamin D-3 binding protein, by Yamamoto. Gc protein, in its properly glycosylated form, is one of the most potent macrophage activators known. It has been used for immunotherapy in terminal cancer patients as well as in late-stage HIV infections.
The activated form of vitamin D3 1,25(OH)2D3 inhibits NFkappa B which is a transcriptional activator of inflammation by physically interact with IKKB. For more detail you can search by above keywords.
In diseases with protein losing enteropaty like colitis or Crohn a vit D deficiency is often encountered, probably by loosing Dbinding protein, lowering the 25OH D3 in blood. In radiation induced intestinal injury a similar mechanism could be responsable for low vit D in blood.
Dear All
Thanks for your response.
Dear Jos,
The study was prospective; we measured vitamin D, then patients underwent radiation therapy. So, the association we observed is less likely be related to the protein losing enteropathy.
Regards
Dear All,
I would like to inform you that our report on the association between vitamin D and radiation proctitis is now published by the Red journals:
http://www.redjournal.org/article/S0360-3016%2815%2900178-9/abstract
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology