Fosfomycin is a bacterial cell wall synthesis inhibitor which can't be grouped into conventional antibiotics i.e. penicillins, cephalosporins, macrolines, quinolones etc. Thus it might be the major effective functional group which one is responsible for exerting its bactericidal action. I want to know the group as I am working on that molecule.
It's a phosphonic acid derivative and a cell-wall active bactericidal agent.Fosfomycin inactivates the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase/MurA.
Based on my little evaluation of the fosfomycin [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid], the functional groups that may be responsible for its action will be the oxiran-2-yl instead of carboxylic group that normally present in PEP [2-phosphonooxyprop-2-enoic acid]. This shift the configuration from organic acid to organophosphoric acid.
I will also conduct further work on this approved drug.
Best regards,
Toluwase H. Fatoki
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