thank you Ali Abdil Razzaq Muhammed Noori Aldallal

Dear Sir,

Citrate maintains acidic pH for longer and prevents crystallization of calcium salts and thereby prevents development of kidney stone.

Citrate is a powerful inhibitor of the crystallization of calcium salts.

Dr.P.A.Vora

Pharma COnsultant

AHmedabad, Gujarat, India

Pl. find attached herewith another article that may give you more clarity.

Dr.P.A.Vora

Pharma COnsultant

AHmedabad, Gujarat, India

[email protected]

Through acidification. Citrates prevent the crystalisation and therefore deposition of oxalate in the kidneys forming stones.

Dear Sir,

There are two reasons that make citrate useful in the treatment of calcium oxalate nephrolithiasis. First of all, it is a calcium complexator. Thus, if citrate is present in high amounts in urine, there are less free calcium (because it is complexed with citrate), and this is traduced in less calcium available to form the calcium oxalate kidney stone. Furthermore, it is a crystallization inhibitor, as it was said previously.

However, citrate consumption does not produce an acidic urine. In fact, it is an alkalinizing substance, and it's widely demonstrated that citrate increases urinary pH.

Here you have one of the articles (there are much more of them) that explain all I have said. I hopes it may helps you.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Preventive+treatment+of+nephrolithiasis+with+alkali+citrate--a+critical+review