It could be a good approach. I hope you know about viruses being used in drug delivery?

Anyways, for use of bacterial system in drug delivery it should be considered that bacteria does not elicit immune response. The bacterial coat could be decorated with ligands that would target it specifically to the cancerous cells. In literature you would find what molecules on cancerous cells could be targeted.

The main problem I think would be to load the bacteria with desired drug molecule. If your desired anticancer molecule is some protein it could also be coated on bacteria.

@ Elbay Malikmammadov and Sumersing Patil

Thanks for your valuable comments. Selection of bacteria is not a big problem neither its immune response as probiotic spp. such as E.coli and lactobacillus are already worked out for other applications. As there are very less articles on this area of work about drug delivery, so it is confusing to consider bacteria as a role model. What will happen if drug loaded bacteria are given intravenously or given orally?

As Mr. Elbay MailkMammadov has said site of injection is important, so does life span of these drug loaded bacteria.

Oral route - but why would you want to do that? What is the rationale, the target(s), the drug kinetics, etc., etc.?

I think the powder form is better for oral adminstration.

Thanks for all comments, @ Zhidong LiU- Oral administration of Live bacteria has some problems, such as high change in pH of oral cavity and stomach of Human, effect of protease and other lytic enzymes and absorption in GI so,sustainability of bacteria will be a question mark. Where as, intravenous injection gives a stable pH but high circulation rate of blood make it difficult to maintain integrity of bacterial surface or attached drug, chances of fast elimination (by excretion is also high ) and high immune response. In the Literature it was stated that live bacteria were given intravenous. However, Frozen dried powdered form of bacteria is desired option because it is easy to administrate.