There is no "accepted" Tx for alcohol withdrawal of which I am aware that uses NMDA antagonists or CC blockers. Are you mostly concerned with acute alcohol withdrawal (inpatient) - e.g. very high blood levels or just in general outpatient population?

Devin Hosea Specifically acute detox. I'm interested in treatments that show promise in mitigating potential cognitive effects of sudden withdrawal from prolonged excessive alcohol use. I'm also separately interested in findings on the effective use of l-theanine and l-glutamine in treatment alcohol withdrawal symptoms/craving management more broadly.

This may be too freewheeling of a query to get a specific answer. I just hope to see more literature on clinical treatment protocols that address some of these considerations.

Thanks for your time and for reading!

No, it's a good question. From an addiction medicine and emergency medicine perspective, I suppose the answers a bit different. First objective is simply to prevent seizure as the alcohol level drops over the first day or so. Second is to stop craving, where things get much harder. I have seen some interesting stuff on pregabalin, for example, which up regulates glutamate, at least if you believe the pharmacokinetic research (speculation). See Patton R, Green G (2017) Alcohol Identification and Intervention in English Emergency Departments, Emergency Medicine Journal 35 (2) pp. 75-78 by Robert A Patton at University of Surrey (formerly with IoPPN/National Addiction Centre at KCL) in the UK and also his general book Addiction: Psychology and Treatment. From a more neuroscientific/neurophysiological/pharmacological perspective I think this is under-researched and worth pursuing.