Hey there Refilwe Mashamaite!

If you're aiming to create gold nanoparticles with a robust pellet, I'd recommend considering a method called citrate reduction. In this process, you typically mix a gold salt solution (like HAuCl4) with sodium citrate under controlled conditions.

Now, for that sturdy pellet, you Refilwe Mashamaite might want to explore variations in the synthesis parameters. Adjusting factors like the concentration of reactants, reaction temperature, and reaction time can influence the size and stability of the nanoparticles, potentially giving you Refilwe Mashamaite a more solid pellet.

Once you've got your gold nanoparticles, the watery pellet issue might be addressed by optimizing the washing steps. Use a centrifuge to separate the nanoparticles from the solution efficiently. Be mindful of the centrifugation speed and duration to ensure a tight pellet.

For encapsulation efficiency and permeability studies, consider employing a reliable surfactant or stabilizing agent during synthesis. This can enhance the stability of your gold nanoparticles during subsequent experiments.

Now, when diving into drug permeability studies, the choice of drug and the encapsulation method become critical. Evaluate different encapsulation techniques to find the one that provides optimal drug loading and release characteristics.

Remember, these are general pointers, and you may need to fine-tune based on your specific requirements and the characteristics you're aiming for in your gold nanoparticles. Good luck with your research!