06 February 2023 0 9K Report

Anti-GD2 CAR expression on the T cells is observed to be downregulated in the subsequent days after activation. The TE reduces from 70% to 40% to 12% going forward in Day 5 to Day 7 to Day 10 respectively, after activation. It seems my CAR has an issue in maintaining its stability, resulting in a transient expression. Are there any means by which I could resolve this?

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