I am checking the antibiotic and a compound combination synergy using checkerboard synergy method. I am doing the assay in 96 well plate. My compound has a brown colour and is soluble in DMSO. Due to this colour, the turbidity caused due to bacterial growth cannot be properly detected using ELISA plate reader. Eventhough I can find a reduction in bacterial growth as it is evident with decreased turbidity, I am not able to give a quantitative result. Kindly suggest a solution.