If to study the effects of kidney disease on patient using only blood samples what all aspects can be screened in blood apart from looking for specific biomarkers (ie., NAG, NGAL, KIM1 etc) and RBC/WBC cell count.
What about genetics/genomics? can it be implicated on blood samples to come to any kind of conclusions about any specific thing?
Using limited resources (ie., blood as the only means of assessment) can we generate enough valuable information to reach a specific conclusion? Ie., in this particular case for example what kind of genetic and biological changes could occur in a kidney disease patient (if cause is due to heavy metal toxicity and not due to hypertension or diabetes) that can be significantly assessed (apart from kidney biomarkers) using blood sample of the patient.
Dear, Total blood haemogram, Renal function test and Liver function test almost advised in most cases of metabolic and pathogenic diseases. TQ
is is impossbile to use the blood as an only screening tool for early kidney disease . I suggest urine sample is very imporatnt . Besides, urine biomarker (KIM-1)is very important . You can try serum component of amyloid A in advanced of CKD disease.
it is impossbile to use the blood as an only screening tool for early kidney disease . I suggest urine sample is very imporatnt . Besides, urine biomarker (KIM-1)is very important . You can try serum component of amyloid A in advanced of CKD disease.
Thank you so much Dr. Chien-liang Chen for your patience reply. What are the crucial genes that are affected in proteinuric chronic kidney disease with tubulointerstitial damage?
1.you must definite proteinuria chronic disease type ?
(nephrotic range proteinuria ? kidney biopsy -- gold standard) minimal change nephropathy or membranous nephropathy or FSGS , then you can check the target gene (podocyte etc) as followings:Kidney International (2004) 66, 571–579; NPHS2 mutation analysis shows genetic heterogeneityof steroid-resistant nephrotic syndrome and lowpost-transplant recurrence
What is the aim of your study ? The tests would depend only on which kidney disease you are studying . Is it AKI , CKD , Glomerular disease or chronic Interstitial disease ? Each of these diseases have specific aetiology & the relevant investigations can be done . Renal biomarkers are useful in early diagnosis of AKI . Even in these , the guidelines are not clear on their role .
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