Hello
I am new to radiotherapy modeling and I've gotten two questions.
What are the safe dose of external beam radiotherapy for brain tumors (Gliomas)?
What are the safe dose of external beam SRT for brain tumors (Gliomas)?
P.S. I need to know if there is any maximum limit for total radiation dose and also for fractions in treating glioma tumors?
Is there any referable reference for this? Please let me know.
Thanks
Wow, answering that is impossible - unless you were to provide all possible information on the position of the tumour(s) and the organs-at-risk, and the treatment machine(s) at your disposal. An oncologist should be consulted, or perhaps more than one. Are you even sure which delivery methodology to use? What equipment do you have? Can you program the radiotherapy machine rather freely, such as utilizing simultaneous movements of the machine head and collimators blocking or enabling beams, "sculpting" the treatment, so to say? It looks to me that you should not be able to get near such a machine before you have taken several courses on the biology of brain tumours, the workings of the machine, and their interactions. :-)
As for the problem, I am quite sure that it is patient and tumour specific.
@Michael Patriksson
Thanks for your answer. I am not an oncologist or a radiologist, so I am not going to use a machine, indeed, I need to simulate the radiotherapy and estimate the optimized dose for treating brain tumors (an optimization research) based on patient's images.So, I just want to use a range that is applicable in clinical cases.
dose to the tumour depends on normal tissue tolerence .Optimum dose to be selected which has maximum tumour control probhabilities (TCP) with minimal Normal Tissue Complication (NTCP).
I agree with my collegues. Many variables playing a role in radiation therapy for gliomas. In genral 60 Gy is the dose for high grade glioma in brain. But several ongoing studies on re-treatment and fractionate radation therapy.
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