The golden key of sinus disease cure is to restore its ventilation & drainage. It is well known the role of sinus mucociliary drainage but no more information about the role of sinus air & its turnover.
Dear Colleague,
I think the sinuses are used as resonances volumes and that function is partially lost when the sinuses are clogged.
They are probably used as well for regulating inhaled air temperature, humidity, pressure
They might also gather and help to spread out before eliminating them, several kind of "impurities" such as odors molecules, dust, nano-particules, etc.
What are your thoughts about it ?
Yours,
bernard
Dear Bernard,
Thanks so much for your contribution. You said probably & might. would you add the articles which support your opinion. This sinus air are renewable or stagnated !!! how is its turnover? is its composition the same during inspiration & expiration? what is its role to prevent sinus infection? would you concentrate your comment on air itself & not the sinuses.
The sinuses lighten the weight of the skull. In addition, another thought is that the role of the pneumocytes that line the sinuses is to produce NO. In the maxillary air sinus, for example, this NO is picked up by inspired air and delivered to the pulmonary alveoli to promote endothelial function for gas exchange. Hope that helps -
Thanks prof. G. Dave for your comment regarding NO. Is there a local role of NO towards the sinus health? Would you detail how the sinus produce NO? is it gas exchange or a chemical reaction using the sinus air? What is about the normal sinus NO concentration? Does the disturbance of this Sinus NO concentration plays a role in the sinus disease development? Thanks again to re-comment on these topics related to the sinus NO.
I think the key to understanding the function of the air sinuses is to focus on their role in the drainage pathways of CSF into the cervical lymphatic system via bone and prelymphatic perineural and perivascular pathways, as implicit in the works of Hippocrates Note: Ethmos = Sieve (Gr).
Dear Anthony, my topic is about the role of air inside the sinuses & not sinuses themselves. Of my knowledge, there is no role of paranasal sinuses regarding CSF drainage. CSF leak per sphenoid, ethmoid, or frontal sinus can be noted in some cases after facial trauma or rarely post-FESS.
"my topic is about the role of air inside the sinuses & not sinuses themselves"
I don't think these roles can be separated. If we don't understand how sinuses formed, and how they drain fluid, we can't know whether the air is a primary or secondary factor. There is a similar problem with mastoid pneumatisation. Is the air inside a well-pneumatised mastoid protecting against otitis media, or do deviant drainage routes predispose to OM and drive out the air?
Good example, Anthony. Note that the mastoid process is formed after a baby develops neck movements - so the mastoid air cells may represent pneumatization in response to sternocleidomastoid muscle function, as the baby's head grows and increases in weight. OM is another big topic, which I won't delve into right now. Just a thought -
Dear DR Hazem ,thank you for your interesting question, it is well known that Nitric oxide (NO) is present in very high concentrations in air derived from the para nasal airways. In contrast, only weak NO synthase activity was found in the epithelium of the nasal cavity (NO) . in humans it is produced by the axons of the epithelial cells in the paranasal sinuses , that(NO) produced during T2R38 ACTIVATION AND THROUGH MULTIPLE CHEMICAL REACTIONS LEADS TO INCREASE CILLIA BEATING . AS WILL (NO) IS AHIGHLY REACTIVE RADICAL THAT CAN DIFFUSE INSIDE THE BACTERIA CELL AND DAMAGE BACTERIA DNA, MEMBRANE LIPIDS AND ENZYMES. IN VITRO(NO) WAS FOUND TO DIFFUSE TO SUERFACE LIQUIED AND HAVE DIRECT BACTERICIDAL EFFECT AGANIST P. AERUGINOSA SO WE CAN CONCLUD THAT THE SINUS AIR PLY ROLE IN SINONASAL INNATE IMMUNITY .
Thank you Prof. Fatma for your valuable comment on my topic. Would you support me & all with detailed source about your valuable comment.
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