The study that seems to be making the most progress is the one being carried out @Queensland University , Australia. The project targeted the main COVID-19 virus enzyme, known as the main protease or Mpro, which plays a pivotal role in mediating viral replication.
This makes it an attractive drug target for this virus, and as people don't naturally have this enzyme, compounds that target it are likely to have low toxicity.Drugs are added directly to the enzyme or to cell cultures growing the virus and assessment made as to how much of each compound is required to stop the enzyme from working or to kill the virus.Should the amount be small, a promising candidate for further studies, is in the pipeline.
Work is proceeding at a very accelerated pace--Man is Racing against Time. Thanks. Stay Safe!!
Article Structure of Mpro from COVID-19 virus and discovery of its inhibitors
Very important and stimulating question looking forward to see valuable comments and information
https://www.theguardian.com/science/2020/mar/19/prospects-treatment-coronavirus-drugs-vaccines
Target protein inhibitors, especially the spike protein, and vaccine
Anything that would disrupt biosynthesis pathways of the virus or that would disrupt it binding with the cognate receptors in mammalian cells.
Ijaz Durrani (click on the picture) Here is a very good article from Science. It includes a diagram. In the diagram, it depicts the detail steps (step-by-step) of how novel coronavirus get into our cells. And, what drugs are under study in which step of the virus coming to a cell are also indicated in the diagram. Attached is a partial of the figure.
https://www.sciencemag.org/news/2020/03/who-launches-global-megatrial-four-most-promising-coronavirus-treatments#
hi sir
could you check this link..please
https://www.theguardian.com/science/2020/mar/19/prospects-treatment-coronavirus-drugs-vaccines
Ijaz Durrani Thanks for this Interesting question that provoked several useful information.
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